PREIMPLANATATION GENETIC DIAGNOSIS/SCREENING
Preimplanatation Genetic Diagnosis/Screening is a reproductive technology used with In Vitro Fertilization (IVF) for screening and diagnosis of genetic diseases in early embryo prior to implantation and pregnancy. The most common type of PGD involves testing of embryos for a panel of common chromosomal abnormalities and using only normal healthy embryos to attempt a pregnancy..
WHAT IS PGD/PGS?
PREIMPLANATATION GENETIC DIAGNOSIS/SCREENING was developed to prevent transfer of serious genetic disorders and to establish gender. It is a two stage process consisting of In Vitro Fertilization (IVF) and genetic screening.
WHO NEEDS PGD/PGS?
PGD can significantly reduce the chances for your baby to be affected with a specific genetic condition or chromosomal abnormality. We will be able to test for many different common genetic diseases in the near future.
STEP BY STEP PGD
1. Preliminary checkup of husband & wife
2. Baseline Hormone Profile of wife
3. Drug treatment (injections) to encourage egg production & maturation
4. Ultra sound monitoring (TVS)
a. Monitor growth of follicles
b. Adjust drug doses
c. Prevent serious side effects i.e. Ovarian Hyper Stimulation Syndrome (OHSS)
5. Monitoring is carried out by:
• Transvaginal ultrasound scanning (TVS)
• Measuring hormone level in blood
6. Egg Pick Up
7. Semen collection and processing
8. ICSI: A single spermatozoon is injected into the egg under special (ICSI) microscope with micromanipulator
9. PGD: Blastomere aspiration carried out at 6-8 cell stage of embryos (day 3 post fertilization)
10. Genetic screening of blastomeres performed through FISH technique
11. Transfer/Implantation of healthy embryos
WHAT ARE THE CHANCES OF SUCCESS?
Chances of conception (getting pregnant) are similar to IVF (30%-40%)
HOW MANY ATTEMPTS OF PGD/PGS CAN BE MADE?
From a medical point of view there is no limit on the number of attempts but one has to consider emotional and financial stress involved in this treatment.